Abstract: From the theoretical perspective of the concept “Four Omnimedia”， which ischaracterized by “whole process， holography， all personnel， and full effect”， this study exploresinnovative paths for efficient operation of theme publishing from four dimensions： informationinteraction to cover the entire space-time， diverse and three-dimensional technology empowermentforms， and diverse subject interactions to “strike a chord with” the audience， shifting frominformation dissemination efficiency to participation in social governance in order to addresssuch key issues facing the efficient operation of theme publishing in the context of deepintegration of publishing as process integration， content and technology integration， changeof operation pattern， and function expansion. Finally， this study puts forward the optimizationstrategies for theme publishing operations from the perspective of “Four Omnimedia”， namely，taking orientation as the soul， and content as priorities； strengthening the systematic thinkingand enhancing the resultant force； adhering to the principle of suitability and making properadaptations； and highlighting openness and dynamic development.