Abstract: Media factors and audience factors of influencing the effects of sci-tech journals agenda-setting were studied. Media factors, such as the nature of issues, report time, source credibility and media influence, are the main factors of influencing the effects of sci-tech journals agenda-setting. Audience factors, such as the frequency of the audience using sci-tech journals, interpersonal discussion, the need for orientation, audience characteristics, are the secondary factors. Aiming at the factors of influencing the effects of sci-tech journals agenda-setting, the article puts forward the measures to improve the effects of agenda-setting: accurate location, focus on content creation, focus on the timeliness of reporting, flexible way of reporting.